F. Murray Abraham became widely known during the 1980s after winning the Academy Award for Best Actor for his role as Antonio Salieri in Amadeus (1984). He has appeared in many roles, both leading and supporting, in films such as All the President's Men (1976), Scarface (1983), The Name of the Rose (1986), Last Action Hero (1993), Star Trek: Insurrection (1998), Finding Forrester (2000), Inside Llewyn Davis (2013) and The Grand Budapest Hotel (2014).

He is also known for his television and theatre work and is now a regular cast member on the award-winning TV series Homeland.